Entamoeba histolytica EhCP112 Dislocates and Degrades Claudin-1 and Claudin-2 at Tight Junctions of the Intestinal Epithelium

Entamoeba histolytica EhCP112 Dislocates and Degrades Claudin-1 and Claudin-2 at Tight Junctions of the Intestinal Epithelium

During intestinal invasion, Entamoeba histolytica opens tight junctions (TJs) reflected by transepithelial electrical resistance (TEER) dropping. To explore the molecular mechanisms underlying this, we studied in vitro and in vivo the damage produced by the recombinant E. histolytica cysteine protea...

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Bibliographic Details
Main Authors: Patricia Cuellar, Elizabeth Hernández-Nava, Guillermina García-Rivera, Bibiana Chávez-Munguía, Michael Schnoor, Abigail Betanzos, Esther Orozco
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Entamoeba histolytica
tight junctions
EhCPADH complex
EhCP112
Caco-2 cells
murine amoebiasis model
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00372/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00372/full

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