NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases

Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction is linked to oxidative stress and reactive oxygen species (ROS) in neurotoxicity during AD. Impaired mitochondrial metabolism has been associated with mitochondrial dysfunction in bra...

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Bibliographic Details
Main Authors: Min Woo Park, Hyeon Woo Cha, Junhyung Kim, Jung Han Kim, Haesung Yang, Sunmi Yoon, Napissara Boonpraman, Sun Shin Yi, Ik Dong Yoo, Jong-Seok Moon
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Redox Biology
Subjects:
NOX4
Ferroptosis
Mitochondrial metabolism
Oxidative stress
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000951

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http://www.sciencedirect.com/science/article/pii/S2213231721000951

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