IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans

IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans

Lipoprotein (a) [Lp(a)] is a highly atherogenic lipid particle. Although earlier reports suggested that Lp(a) levels are mostly determined by genetic factors, several recent studies have revealed that Lp(a) induction is also caused by chronic inflammation. Therefore, we aimed to examine whether cyto...

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Bibliographic Details
Main Authors: Nike Müller, Dominik M. Schulte, Kathrin Türk, Sandra Freitag-Wolf, Jochen Hampe, Rainald Zeuner, Johann O. Schröder, Ioanna Gouni-Berthold, Heiner K. Berthold, Wilhelm Krone, Stefan Rose-John, Stefan Schreiber, Matthias Laudes
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Journal of Lipid Research
Subjects:
interleukin
acute phase response
inflammation
therapy of elevated Lp(a)
lipoprotein metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520312438

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http://www.sciencedirect.com/science/article/pii/S0022227520312438

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