Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy

Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy

One of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in tumors. Tumor cells generally display the higher oxidative level than normal cells, and also displayed the heterogeneity in terms of redox homeostasis level. We previously found that...

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Bibliographic Details
Main Authors: Bin Yang, Lin Wei, Yuequan Wang, Na Li, Bin Ji, Kaiyuan Wang, Xuanbo Zhang, Shenwu Zhang, Shuang Zhou, Xiaohui Yao, Hang Song, Yusheng Wu, Haotian Zhang, Qiming Kan, Tao Jin, Jin Sun
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Prodrug nanoplatform
Disulfide bond
Pyropheophorbide a
Redox-heterogeneity
Accurate therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S181808761930786X

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http://www.sciencedirect.com/science/article/pii/S181808761930786X

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