Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells

Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells

Aneuploidy disrupts cellular homeostasis. However, the molecular mechanisms underlying the physiological responses and adaptation to aneuploidy are not well understood. Deciphering these mechanisms is important because aneuploidy is associated with diseases, including intellectual disability and can...

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Bibliographic Details
Main Authors: Sunyoung Hwang, H. Tobias Gustafsson, Ciara O’Sullivan, Gianna Bisceglia, Xinhe Huang, Christian Klose, Andrej Schevchenko, Robert C. Dickson, Paola Cavaliere, Noah Dephoure, Eduardo M. Torres
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
aneuploidy
serine
sphingolipids
ceramide
long-chain bases
sphingosine
genomic istability
chromosomes
metabolism
myriocin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317874

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http://www.sciencedirect.com/science/article/pii/S2211124717317874

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