TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’s Disease

TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with cognitive deficits and synaptic impairments. Amyloid-β (Aβ) plaque deposition, dystrophic neurite accumulation and neurofibrillary tangles are pathological hallmarks of AD. TMEM59 has been implicated to play a role i...

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Bibliographic Details
Main Authors: Jian Meng, Linkun Han, Naizhen Zheng, Hui Xu, Zhaoji Liu, Xian Zhang, Hong Luo, Dan Can, Hao Sun, Huaxi Xu, Yun-wu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Alzheimer’s disease
amyloid-β
cognitive deficits
neurite dystrophy
synaptic plasticity
TMEM59
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.596030/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.596030/full

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