Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease

Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease

Abstract Epigenetic deregulation of α‐synuclein plays a key role in Parkinson’s disease (PD). Analysis of the SNCA promoter using the ENCODE database revealed the presence of important histone post‐translational modifications (PTMs) including transcription‐promoting marks, H3K4me3 and H3K27ac, and r...

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Bibliographic Details
Main Authors: Subhrangshu Guhathakurta, Jinil Kim, Levi Adams, Sambuddha Basu, Min Kyung Song, Evan Adler, Goun Je, Mariana Bernardo Fiadeiro, Yoon‐Seong Kim
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:EMBO Molecular Medicine
Subjects:
CRISPR/Cas9
histone post‐translational modifications
iPSCs
Parkinson’s disease
α‐synuclein
Online Access:https://doi.org/10.15252/emmm.202012188

Internet

https://doi.org/10.15252/emmm.202012188

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