Generation of a human iPSC line harboring a biallelic large deletion at the INK4 locus (HMGUi001-A-5)

Generation of a human iPSC line harboring a biallelic large deletion at the INK4 locus (HMGUi001-A-5)

The INK4 locus is considered as a hot-spot region for the complex genetic disorders, including cancer, type 2 diabetes (T2D) and coronary artery disease (CAD). By CRISPR/Cas9 gene editing, we generated a human induced pluripotent stem cell (hiPSC) line (HMGUi001-A-5) deleting an 8 kb genomic DNA enc...

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Bibliographic Details
Main Authors: Alireza Shahryari, Noel Moya, Johanna Siehler, Xianming Wang, Anna Karolina Blöchinger, Ingo Burtscher, Mostafa Bakhti, Seyed Javad Mowla, Heiko Lickert
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120302282

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http://www.sciencedirect.com/science/article/pii/S1873506120302282

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