Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide.

Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide.

BACKGROUND: Aberrant cap-dependent translation is implicated in tumorigenesis in multiple tumor types including mesothelioma. In this study, disabling the eIF4F complex by targeting eIF4E with eIF4E-specific antisense oligonucleotide (4EASO) is assessed as a therapy for mesothelioma. METHODS: Mesoth...

Full description

Bibliographic Details
Main Authors: Blake A Jacobson, Saritha C Thumma, Joseph Jay-Dixon, Manish R Patel, K Dubear Kroening, Marian G Kratzke, Ryan G Etchison, Bruce W Konicek, Jeremy R Graff, Robert A Kratzke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3832430?pdf=render

Internet

http://europepmc.org/articles/PMC3832430?pdf=render

Similar Items