Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway

Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway

Rabies is an ancient disease but remains endemic in most parts of the world and causes approximately 59,000 deaths annually. The mechanism through which the causative agent, rabies virus (RABV), evades the host immune response and infects the host central nervous system (CNS) has not been completely...

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Bibliographic Details
Main Authors: Bin Tian, Ming Zhou, Yu Yang, Lan Yu, Zhaochen Luo, Dayong Tian, Ke Wang, Min Cui, Huanchun Chen, Zhen F. Fu, Ling Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
rabies virus
astrocytes
double-strand RNA
cytokine expression
mitochondrial antiviral-signaling protein signaling pathway
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.02011/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.02011/full

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