LETM1 couples mitochondrial DNA metabolism and nutrient preference

LETM1 couples mitochondrial DNA metabolism and nutrient preference

Abstract The diverse clinical phenotypes of Wolf–Hirschhorn syndrome (WHS) are the result of haploinsufficiency of several genes, one of which, LETM1, encodes a protein of the mitochondrial inner membrane of uncertain function. Here, we show that LETM1 is associated with mitochondrial ribosomes, is...

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Bibliographic Details
Main Authors: Romina Durigon, Alice L Mitchell, Aleck WE Jones, Andreea Manole, Mara Mennuni, Elizabeth MA Hirst, Henry Houlden, Giuseppe Maragni, Serena Lattante, Paolo Niccolo’ Doronzio, Ilaria Dalla Rosa, Marcella Zollino, Ian J Holt, Antonella Spinazzola
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:EMBO Molecular Medicine
Subjects:
LETM1
mitochondrial DNA
mitochondrial morphology
nutrient utilization
Wolf–Hirschhorn syndrome
Online Access:https://doi.org/10.15252/emmm.201708550

Internet

https://doi.org/10.15252/emmm.201708550

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