Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii. However, polymyxin resistance can emerge with monotherapy, highlighting the need for synergistic combination therapies. Polymyxins in combination with β-lactams have shown remarkable syne...

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Bibliographic Details
Main Authors: Mei-Ling Han, Xiaofen Liu, Tony Velkov, Yu-Wei Lin, Yan Zhu, Darren J. Creek, Christopher K. Barlow, Heidi H. Yu, Zhihui Zhou, Jing Zhang, Jian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
polymyxin
β-lactam
combination therapy
lipopolysaccharide
peptidoglycan
metabolomics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00754/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00754/full

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