Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface

Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface

Down regulation of the major histocompatibility class (MHC) I pathway plays an important role in tumour development, and can be achieved by suppression of HLA expression or mutations in the MHC peptide-binding pocket. The peptide-loading complex (PLC) loads peptides on the MHC-I molecule in a dynami...

Full description

Bibliographic Details
Main Authors: Monikaben Padariya, Umesh Kalathiya, Douglas R. Houston, Javier Antonio Alfaro
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
tapasin
erp57
mhc-i
peptide loading complex
molecular dynamics
stability change
cbioportal
protein–protein interactions
cancer mutations
Online Access:https://www.mdpi.com/2072-6694/12/3/737

Internet

https://www.mdpi.com/2072-6694/12/3/737

Similar Items