Identification of TAZ-Dependent Breast Cancer Vulnerabilities Using a Chemical Genomics Screening Approach

Identification of TAZ-Dependent Breast Cancer Vulnerabilities Using a Chemical Genomics Screening Approach

Breast cancer stem cells (BCSCs) represent a subpopulation of tumor cells that can self-renew and generate tumor heterogeneity. Targeting BCSCs may ameliorate therapy resistance, tumor growth, and metastatic progression. However, the origin and molecular mechanisms underlying their cellular properti...

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Bibliographic Details
Main Authors: He Shen, Yanmin Chen, Yin Wan, Tao Liu, Jianmin Wang, Yali Zhang, Lei Wei, Qiang Hu, Bo Xu, Mikhail Chernov, Costa Frangou, Jianmin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Hippo pathway
TAZ
breast cancer
stem cells
small molecule
Cyclin D
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.673374/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.673374/full

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