Interleukin-6 Induces Myogenic Differentiation via JAK2-STAT3 Signaling in Mouse C2C12 Myoblast Cell Line and Primary Human Myoblasts

Interleukin-6 Induces Myogenic Differentiation via JAK2-STAT3 Signaling in Mouse C2C12 Myoblast Cell Line and Primary Human Myoblasts

Postnatal muscle growth and exercise- or injury-induced regeneration are facilitated by myoblasts. Myoblasts respond to a variety of proteins such as cytokines that activate various signaling cascades. Cytokines belonging to the interleukin 6 superfamily (IL-6) influence myoblasts’ prolife...

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Bibliographic Details
Main Authors: Paul J. Steyn, Kevin Dzobo, Robert I. Smith, Kathryn H. Myburgh
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
muscle
myogenesis
satellite cells
myoblasts
il-6
interleukins
jak-stat signaling
differentiation
proliferation
regeneration
Online Access:https://www.mdpi.com/1422-0067/20/21/5273

Internet

https://www.mdpi.com/1422-0067/20/21/5273

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