High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny.
Decades ago, the "immortal strand hypothesis" was proposed as a means by which stem cells might limit acquiring mutations that could give rise to cancer, while continuing to proliferate for the life of an organism. Originally based on observations in embryonic cells, and later studied in t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-05-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC1852584?pdf=render |