PD-1 Expression on Mycobacterium tuberculosis-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis

PD-1 Expression on Mycobacterium tuberculosis-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis

Persistent antigen stimulation in chronic infections has been associated with antigen-specific T cell dysfunction and upregulation of inhibitory receptors, including programmed cell death protein 1 (PD-1). Pulmonary tuberculosis (TB) disease is characterized by high levels of Mycobacterium tuberculo...

Full description

Bibliographic Details
Main Authors: Cheryl L. Day, Deborah A. Abrahams, Rubina Bunjun, Lynnett Stone, Marwou de Kock, Gerhard Walzl, Robert J. Wilkinson, Wendy A. Burgers, Willem A. Hanekom
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
CD4 T cell
CD8 T cell
tuberculosis
PD-1
IFN-γ
proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01995/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01995/full

Similar Items