Novel pharmacotherapy: NNI-362, an allosteric p70S6 kinase stimulator, reverses cognitive and neural regenerative deficits in models of aging and disease

Novel pharmacotherapy: NNI-362, an allosteric p70S6 kinase stimulator, reverses cognitive and neural regenerative deficits in models of aging and disease

Abstract Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression which is exacerbated in chronic neurodegenerative disorders, e.g., Alzheimer’s diseas...

Full description

Bibliographic Details
Main Authors: Nathalie Sumien, Matthew S. Wells, Akram Sidhu, Jessica M. Wong, Michael J. Forster, Qiao-Xi Zheng, Judith A. Kelleher-Andersson
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Alzheimer’s disease
mTOR/p70S6 kinase axis
Allosteric modulator
Human neural progenitors
Hippocampal neuron regeneration
BrdU+ neuron survival
Online Access:https://doi.org/10.1186/s13287-020-02126-3

Internet

https://doi.org/10.1186/s13287-020-02126-3

Similar Items