Structural Features of Heparin and Its Interactions With Cellular Prion Protein Measured by Surface Plasmon Resonance

Structural Features of Heparin and Its Interactions With Cellular Prion Protein Measured by Surface Plasmon Resonance

Self-propagating form of the prion protein (PrPSc) causes many neurodegenerative diseases, such as Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler-Scheinker syndrome (GSS). Heparin is a highly sulfated linear glycosaminoglycan (GAG) and is composed of alternating D-glucosamine and L-iduroni...

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Bibliographic Details
Main Authors: So Young Kim, Fuming Zhang, David A. Harris, Robert J. Linhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
heparin
interaction
prion protein
surface plasmon resonance
glycosaminoglycan
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.594497/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2020.594497/full

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