A novel fully automated molecular diagnostic system (AMDS) for colorectal cancer mutation detection.

A novel fully automated molecular diagnostic system (AMDS) for colorectal cancer mutation detection.

BACKGROUND: KRAS, BRAF and PIK3CA mutations are frequently observed in colorectal cancer (CRC). In particular, KRAS mutations are strong predictors for clinical outcomes of EGFR-targeted treatments such as cetuximab and panitumumab in metastatic colorectal cancer (mCRC). For mutation analysis, the c...

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Main Authors: Shiro Kitano, Jamie Myers, Junko Nakamura, Akio Yamane, Mami Yamashita, Masato Nakayama, Yusuke Tsukahara, Hiroshi Ushida, Wanqing Liu, Mark J Ratain, Masahiko Amano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3650034?pdf=render

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http://europepmc.org/articles/PMC3650034?pdf=render

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