Live attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primates.

Live attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primates.

Francisella tularensis causes the disease tularemia. Human pulmonary exposure to the most virulent form, F. tularensis subsp. tularensis (Ftt), leads to high morbidity and mortality, resulting in this bacterium being classified as a potential biothreat agent. However, a closely-related species, F. n...

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Bibliographic Details
Main Authors: Ping Chu, Aimee L Cunningham, Jieh-Juen Yu, Jesse Q Nguyen, Jeffrey R Barker, C Rick Lyons, Julie Wilder, Michelle Valderas, Robert L Sherwood, Bernard P Arulanandam, Karl E Klose
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4207810?pdf=render

Internet

http://europepmc.org/articles/PMC4207810?pdf=render

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