The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

In vivo, the primary molecular mechanotransductive events mechanically initiating cell differentiation remain unknown. Here we find the molecular stretching of the highly conserved Y654-β-catenin-D665-E-cadherin binding site as mechanically induced by tissue strain. It triggers the increase of acces...

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Bibliographic Details
Main Authors: Jens-Christian Röper, Démosthène Mitrossilis, Guillaume Stirnemann, François Waharte, Isabel Brito, Maria-Elena Fernandez-Sanchez, Marc Baaden, Jean Salamero, Emmanuel Farge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
mechanotransduction
beta-catenin
gastrulation
FRET-FLIM
molecular dynamic simulations
Online Access:https://elifesciences.org/articles/33381

Internet

https://elifesciences.org/articles/33381

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