Mitochondrial Mechanisms of LRRK2 G2019S Penetrance

Mitochondrial Mechanisms of LRRK2 G2019S Penetrance

Several mutations in leucine-rich repeat kinase-2 (LRRK2) have been associated with Parkinson's disease (PD). The most common substitution, G2019S, interferes with LRRK2 kinase activity, which is regulated by autophosphorylation. Yet, the penetrance of this gain-of-function mutation is incomple...

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Bibliographic Details
Main Authors: Sylvie Delcambre, Jenny Ghelfi, Nassima Ouzren, Léa Grandmougin, Catherine Delbrouck, Philip Seibler, Kobi Wasner, Jan O. Aasly, Christine Klein, Joanne Trinh, Sandro L. Pereira, Anne Grünewald
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neurology
Subjects:
leucine-rich repeat kinase-2 (LRRK2)
G2019S
Parkinson's disease
penetrance
mitochondria
mitochondrial DNA (mtDNA)
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00881/full

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https://www.frontiersin.org/article/10.3389/fneur.2020.00881/full

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