ZZ-dependent regulation of p62/SQSTM1 in autophagy

ZZ-dependent regulation of p62/SQSTM1 in autophagy

The autophagic receptor p62 recognizes arginylated (Nt-R) substrates through its ZZ domain (p62ZZ). Here the authors identify a p62 auto regulatory mechanism and provide structural insights into the selective recognition of Nt-R by p62ZZ and further show that Nt-R binding stimulates p62 oligomerizat...

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Bibliographic Details
Main Authors: Yi Zhang, Su Ran Mun, Juan F. Linares, JaeWoo Ahn, Christina G. Towers, Chang Hoon Ji, Brent E. Fitzwalter, Michael R. Holden, Wenyi Mi, Xiaobing Shi, Jorge Moscat, Andrew Thorburn, Maria T. Diaz-Meco, Yong Tae Kwon, Tatiana G. Kutateladze
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06878-8

Internet

https://doi.org/10.1038/s41467-018-06878-8

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