Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100.

Incubation of low density lipoprotein (LDL) with endothelial cells converts it to a form that is avidly degraded by macrophages via the acetyl LDL receptor. This modification has previously been shown to be accompanied by extensive breakdown of the major LDL protein (apoB-100) to smaller peptides. A...

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Bibliographic Details
Main Authors: L G Fong, S Parthasarathy, J L Witztum, D Steinberg
Format: Article
Language:English
Published: Elsevier 1987-12-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752038576X