Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant progress has been made in elucidating the genetics of T1D in recent years, the non...

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Main Authors: Vardhman K Rakyan, Huriya Beyan, Thomas A Down, Mohammed I Hawa, Siarhei Maslau, Deeqo Aden, Antoine Daunay, Florence Busato, Charles A Mein, Burkhard Manfras, Kerith-Rae M Dias, Christopher G Bell, Jörg Tost, Bernhard O Boehm, Stephan Beck, R David Leslie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3183089?pdf=render

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http://europepmc.org/articles/PMC3183089?pdf=render

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