The Antifungal Mechanism of Amphotericin B Elucidated in Ergosterol and Cholesterol-Containing Membranes Using Neutron Reflectometry

The Antifungal Mechanism of Amphotericin B Elucidated in Ergosterol and Cholesterol-Containing Membranes Using Neutron Reflectometry

We have characterized and compared the structures of ergosterol- and cholesterol-containing 1-palmitoyl-2-oleoyl-<i>sn</i>-glycero-3-phosphocholine (POPC) membranes before and after interaction with the amphiphilic antifungal drug amphotericin B (AmB) using neutron reflection. AmB insert...

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Bibliographic Details
Main Authors: Robin Delhom, Andrew Nelson, Valerie Laux, Michael Haertlein, Wolfgang Knecht, Giovanna Fragneto, Hanna P. Wacklin-Knecht
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Nanomaterials
Subjects:
amphotericin B
lipid membranes
POPC
ergosterol
cholesterol
neutron reflection
Online Access:https://www.mdpi.com/2079-4991/10/12/2439

Internet

https://www.mdpi.com/2079-4991/10/12/2439

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