The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers

The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers

To understand how the Bcl6 transcriptional repressor functions in the immune system, we disrupted its RD2 repression domain in mice. Bcl6RD2MUT mice exhibit a complete loss of germinal center (GC) formation but retain normal extrafollicular responses. Bcl6RD2MUT antigen-engaged B cells migrate to th...

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Bibliographic Details
Main Authors: Chuanxin Huang, David G. Gonzalez, Christine M. Cote, Yanwen Jiang, Katerina Hatzi, Matt Teater, Kezhi Dai, Timothy Hla, Ann M. Haberman, Ari Melnick
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714006627

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http://www.sciencedirect.com/science/article/pii/S2211124714006627

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