Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

<p>Abstract</p> <p>Background</p> <p>The Akt/PKB family of kinases is frequently activated in human cancers, including oral squamous cell carcinoma (OSCC). Akt-induced epithelial-to-mesenchymal transition (EMT) involves downregulation of E-cadherin, which appears to res...

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Bibliographic Details
Main Authors: Hong Sam-Pyo, Lee Jae-Il, Yoon Hye-Jung, Hong Ji-Soo, Kim Ji-Hong, Hong Kyoung-Ok, Hong Seong-Doo
Format: Article
Language:English
Published: BMC 2009-02-01
Series:Journal of Experimental & Clinical Cancer Research
Online Access:http://www.jeccr.com/content/28/1/28

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http://www.jeccr.com/content/28/1/28

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