Telomere Maintenance Mechanisms in Cancer

Telomere Maintenance Mechanisms in Cancer

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-i...

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Bibliographic Details
Main Authors: Tiago Bordeira Gaspar, Ana Sá, José Manuel Lopes, Manuel Sobrinho-Simões, Paula Soares, João Vinagre
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Genes
Subjects:
cancer
telomere
telomerase
promoter
TERT
TERC
alternative lengthening of telomeres (ALT)
telomere maintenance mechanism (TMM)
non-defined telomere maintenance mechanism (NDTMM)
Online Access:http://www.mdpi.com/2073-4425/9/5/241

Internet

http://www.mdpi.com/2073-4425/9/5/241

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