20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease

20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease

20-HETE is a potent vasoconstrictor that is implicated in the regulation of blood pressure, cerebral blood flow and neuronal death following ischemia. Numerous human genetic studies have shown that inactivating variants in the cytochrome P450 enzymes that produce 20-HETE are associated with hyperten...

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Bibliographic Details
Main Authors: Ezekiel Gonzalez-Fernandez, Daniel Staursky, Kathryn Lucas, Bond V. Nguyen, Man Li, Yedan Liu, Chad Washington, Lique M. Coolen, Fan Fan, Richard J. Roman
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neurology
Subjects:
20-HETE
GPR75
neurovascular unit (NVU)
blood brain barrier (BBB)
cerebral blood flow (CBF)
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00983/full

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https://www.frontiersin.org/article/10.3389/fneur.2020.00983/full

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