Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

Recently evolved alleles of Apolipoprotein L-1 (APOL1) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infections by forming ion channels within the parasite, ca...

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Bibliographic Details
Main Authors: Joseph A Giovinazzo, Russell P Thomson, Nailya Khalizova, Patrick J Zager, Nirav Malani, Enrique Rodriguez-Boulan, Jayne Raper, Ryan Schreiner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
protein trafficking
membrane channels
ion channel
apolipoprotein l1
polymorphism
Online Access:https://elifesciences.org/articles/51185

Internet

https://elifesciences.org/articles/51185

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