Synthesis of Novel 1-Substituted and 1,9-Disubstituted-1,2,3,4-tetrahydro-9H-Carbazole Derivatives as Potential Anticancer Agents

Synthesis of Novel 1-Substituted and 1,9-Disubstituted-1,2,3,4-tetrahydro-9H-Carbazole Derivatives as Potential Anticancer Agents

Condensation of 1-acetyl-1,2,3,4-tetrahydro-9H-carbazole (2) with some amino compounds furnished the corresponding imino derivatives 3a-e. Compound 3a reacted with chloroacetic acid and underwent cyclization to give the thiazolidine derivative 5. Also, treatment of 3c with thionyl chloride caused cy...

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Bibliographic Details
Main Authors: H. I. El-Diwani, A. M. Soliman, M. M.F. Ismail, N. A. M. M. Shmeiss
Format: Article
Language:English
Published: MDPI AG 2000-10-01
Series:Molecules
Subjects:
Carbazole derivatives
thiadiazino derivatives
cytotoxic activity
Online Access:http://www.mdpi.com/1420-3049/5/10/1101/

Internet

http://www.mdpi.com/1420-3049/5/10/1101/

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