3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

Studies examining human podocytopathies have utilised 2D cultured primary or immortalised podocyte cell lines. Here, the authors demonstrate that 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney organoids retain an improved podocyte identity in vitro facilitating disease m...

Full description

Bibliographic Details
Main Authors: Lorna J. Hale, Sara E. Howden, Belinda Phipson, Andrew Lonsdale, Pei X. Er, Irene Ghobrial, Salman Hosawi, Sean Wilson, Kynan T. Lawlor, Shahnaz Khan, Alicia Oshlack, Catherine Quinlan, Rachel Lennon, Melissa H. Little
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07594-z

Internet

https://doi.org/10.1038/s41467-018-07594-z

Similar Items