Glucocorticoid receptor beta splice variant expression in patients with high and low activity of systemic lupus erythematosus.
The glucocorticoid receptor (GR) occurs mainly in two alternative splice variants encoding GRalpha and GRbeta. The GRbeta variant does not contain a GC binding domain and cannot mediate anti-inflammatory GC effects. Peripheral blood mononuclear cells (PBMCs) were isolated from venous whole blood of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2008-01-01
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| Series: | Folia Histochemica et Cytobiologica |
| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/4505 |