c-Jun NH<sub>2</sub>-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL

c-Jun NH<sub>2</sub>-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL

<p>Abstract</p> <p>Background</p> <p>Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apoptosis. The current stud...

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Bibliographic Details
Main Authors: Chen Georgia Z, Tao Hui, Li Bo, Oh Youtake, Yue Ping, Elrod Heath A, Lin Yi-Dan, Fu Lei, Shin Dong M, Khuri Fadlo R, Sun Shi-Yong
Format: Article
Language:English
Published: BMC 2010-12-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/315

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http://www.molecular-cancer.com/content/9/1/315

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