c-Jun NH<sub>2</sub>-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL
<p>Abstract</p> <p>Background</p> <p>Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apoptosis. The current stud...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2010-12-01
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Series: | Molecular Cancer |
Online Access: | http://www.molecular-cancer.com/content/9/1/315 |