Celastrol Attenuates Lipid Accumulation and Stemness of Clear Cell Renal Cell Carcinoma via CAV-1/LOX-1 Pathway

Celastrol Attenuates Lipid Accumulation and Stemness of Clear Cell Renal Cell Carcinoma via CAV-1/LOX-1 Pathway

Clear cell renal cell carcinoma (ccRCC) is characterized by abnormal lipid accumulation. Celastrol is a pentacyclic triterpene extracted from Tripterygium wilfordii Hook F with anti-cancer activity. In the present study, the anticancer effects of celastrol on ccRCC and the underlying mechanisms were...

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Bibliographic Details
Main Authors: Chan-Juan Zhang, Neng Zhu, Yu-Xiang Wang, Le-Ping Liu, Tan-Jun Zhao, Hong-Tao Wu, Duan-Fang Liao, Li Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
celastrol
clear cell renal cell carcinoma
lipid accumulation
stemness
cav-1
LOX-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.658092/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.658092/full

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