Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies
Chronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and deterioration of lung function. Rhinovirus is the mos...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01270/full |
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English |
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Article |
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DOAJ |
| author |
Kak-Ming Ling Kak-Ming Ling Luke W. Garratt Timo Lassmann Stephen M. Stick Stephen M. Stick Stephen M. Stick Stephen M. Stick Anthony Kicic Anthony Kicic Anthony Kicic Anthony Kicic Anthony Kicic WAERP AusREC AusREC AusREC Australian Respiratory Early Surveillance Team for Cystic Fibrosis Australian Respiratory Early Surveillance Team for Cystic Fibrosis Australian Respiratory Early Surveillance Team for Cystic Fibrosis Australian Respiratory Early Surveillance Team for Cystic Fibrosis |
| spellingShingle |
Kak-Ming Ling Kak-Ming Ling Luke W. Garratt Timo Lassmann Stephen M. Stick Stephen M. Stick Stephen M. Stick Stephen M. Stick Anthony Kicic Anthony Kicic Anthony Kicic Anthony Kicic Anthony Kicic WAERP AusREC AusREC AusREC Australian Respiratory Early Surveillance Team for Cystic Fibrosis Australian Respiratory Early Surveillance Team for Cystic Fibrosis Australian Respiratory Early Surveillance Team for Cystic Fibrosis Australian Respiratory Early Surveillance Team for Cystic Fibrosis Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies Frontiers in Pharmacology cystic fibrosis airway epithelium rhinovirus innate immune response therapy transcriptomic |
| author_facet |
Kak-Ming Ling Kak-Ming Ling Luke W. Garratt Timo Lassmann Stephen M. Stick Stephen M. Stick Stephen M. Stick Stephen M. Stick Anthony Kicic Anthony Kicic Anthony Kicic Anthony Kicic Anthony Kicic WAERP AusREC AusREC AusREC Australian Respiratory Early Surveillance Team for Cystic Fibrosis Australian Respiratory Early Surveillance Team for Cystic Fibrosis Australian Respiratory Early Surveillance Team for Cystic Fibrosis Australian Respiratory Early Surveillance Team for Cystic Fibrosis |
| author_sort |
Kak-Ming Ling |
| title |
Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies |
| title_short |
Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies |
| title_full |
Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies |
| title_fullStr |
Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies |
| title_full_unstemmed |
Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies |
| title_sort |
elucidating the interaction of cf airway epithelial cells and rhinovirus: using the host-pathogen relationship to identify future therapeutic strategies |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Pharmacology |
| issn |
1663-9812 |
| publishDate |
2018-11-01 |
| description |
Chronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and deterioration of lung function. Rhinovirus is the most prevalent respiratory virus detected, particularly during exacerbations in children with CF <5 years old. However, even though rhinoviral infections are likely to be one of the factors initiating the onset of CF lung disease, there is no effective targeted treatment. A better understanding of the innate immune responses by CF airway epithelial cells, the primary site of infection for viruses, is needed to identify why viral infections are more severe in CF. The aim of this review is to present the clinical impact of virus infection in both young children and adults with CF, focusing on rhinovirus infection. Previous in vitro and in vivo investigations looking at the mechanisms behind virus infection will also be summarized. The review will finish on the potential of transcriptomics to elucidate the host-pathogen responses by CF airway cells to viral infection and identify novel therapeutic targets. |
| topic |
cystic fibrosis airway epithelium rhinovirus innate immune response therapy transcriptomic |
| url |
https://www.frontiersin.org/article/10.3389/fphar.2018.01270/full |
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doaj-1f28780486404eeaa2d400272e238b362020-11-24T21:23:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-11-01910.3389/fphar.2018.01270416929Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic StrategiesKak-Ming Ling0Kak-Ming Ling1Luke W. Garratt2Timo Lassmann3Stephen M. Stick4Stephen M. Stick5Stephen M. Stick6Stephen M. Stick7Anthony Kicic8Anthony Kicic9Anthony Kicic10Anthony Kicic11Anthony Kicic12WAERP13AusREC14AusREC15AusREC16Australian Respiratory Early Surveillance Team for Cystic Fibrosis17Australian Respiratory Early Surveillance Team for Cystic Fibrosis18Australian Respiratory Early Surveillance Team for Cystic Fibrosis19Australian Respiratory Early Surveillance Team for Cystic Fibrosis20Paediatrics, Medical School, Faculty of Healthy and Medical Science, University of Western Australia, Nedlands, WA, AustraliaTelethon Kids Institute, University of Western Australia, Nedlands, WA, AustraliaTelethon Kids Institute, University of Western Australia, Nedlands, WA, AustraliaTelethon Kids Institute, University of Western Australia, Nedlands, WA, AustraliaPaediatrics, Medical School, Faculty of Healthy and Medical Science, University of Western Australia, Nedlands, WA, AustraliaTelethon Kids Institute, University of Western Australia, Nedlands, WA, AustraliaDepartment of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, WA, AustraliaCentre for Cell Therapy and Regenerative Medicine, School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, AustraliaPaediatrics, Medical School, Faculty of Healthy and Medical Science, University of Western Australia, Nedlands, WA, AustraliaTelethon Kids Institute, University of Western Australia, Nedlands, WA, AustraliaDepartment of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, WA, AustraliaCentre for Cell Therapy and Regenerative Medicine, School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, AustraliaOccupation and Environment, School of Public Health, Curtin University, Bentley, WA, AustraliaPaediatrics, Medical School, Faculty of Healthy and Medical Science, University of Western Australia, Nedlands, WA, AustraliaPaediatrics, Medical School, Faculty of Healthy and Medical Science, University of Western Australia, Nedlands, WA, AustraliaRobinson Research Institute, University of Adelaide, Adelaide, SA, AustraliaHunter Medical Research Institute: Priority Research Centre for Asthma and Respiratory Disease, New Lambton Heights, NSW, AustraliaPaediatrics, Medical School, Faculty of Healthy and Medical Science, University of Western Australia, Nedlands, WA, AustraliaDepartment of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, WA, AustraliaMurdoch Children's Research Institute, Melbourne, VIC, AustraliaDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, AustraliaChronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and deterioration of lung function. Rhinovirus is the most prevalent respiratory virus detected, particularly during exacerbations in children with CF <5 years old. However, even though rhinoviral infections are likely to be one of the factors initiating the onset of CF lung disease, there is no effective targeted treatment. A better understanding of the innate immune responses by CF airway epithelial cells, the primary site of infection for viruses, is needed to identify why viral infections are more severe in CF. The aim of this review is to present the clinical impact of virus infection in both young children and adults with CF, focusing on rhinovirus infection. Previous in vitro and in vivo investigations looking at the mechanisms behind virus infection will also be summarized. The review will finish on the potential of transcriptomics to elucidate the host-pathogen responses by CF airway cells to viral infection and identify novel therapeutic targets.https://www.frontiersin.org/article/10.3389/fphar.2018.01270/fullcystic fibrosisairway epitheliumrhinovirusinnate immune responsetherapytranscriptomic |