Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production

Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production

STAT2 is a central component of the ISGF3 transcriptional complex downstream of type I interferon (IFN-I) signaling. The significance of in vivo IFN-I/STAT1 signals in cDCs is well-established in the generation of antitumor cytotoxic T cell (CTL) responses. However, the role of STAT2 has remained el...

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Bibliographic Details
Main Authors: Connie C. Qiu, Kevin P. Kotredes, Tess Cremers, Sajan Patel, Alexandra Afanassiev, Michael Slifker, Stefania Gallucci, Ana M. Gamero
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
stat2
dendritic cells
t cell
interferon
tumor
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1860477

Internet

http://dx.doi.org/10.1080/2162402X.2020.1860477

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