Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2

Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2

MDM2 regulates a variety of cellular processes through its dual protein:protein interaction and ubiquitin ligase activities. One major function of MDM2 is to bind and ubiquitinate P53, thereby regulating its proteasomal degradation. This function is in turn controlled by the cell fate determinant NU...

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Bibliographic Details
Main Authors: Stefano Confalonieri, Ivan Nicola Colaluca, Andrea Basile, Salvatore Pece, Pier Paolo Di Fiore
Format: Article
Language:English
Published: Oxford University Press 2019-10-01
Series:G3: Genes, Genomes, Genetics
Subjects:
NUMB
MDM2
exon gain
chordate evolution
PTB domain
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400494

Internet

http://g3journal.org/lookup/doi/10.1534/g3.119.400494

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