Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9

Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9

Abstract Background Currently, the numerous and versatile applications in pharmaceutical and chemical industry make the recombinant production of cytochrome P450 enzymes (CYPs) of great biotechnological interest. Accelerating the drug development process by simple, quick and scalable access of human...

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Bibliographic Details
Main Authors: Javier Garrigós-Martínez, Astrid Weninger, José Luis Montesinos-Seguí, Christian Schmid, Francisco Valero, Claudia Rinnofner, Anton Glieder, Xavier Garcia-Ortega
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Microbial Cell Factories
Subjects:
Bidirectional promoters
Human CYP2C9
Ibuprofen
Pichia pastoris
Bioprocess optimisation
Whole cell biocatalyst
Online Access:https://doi.org/10.1186/s12934-021-01577-4

Internet

https://doi.org/10.1186/s12934-021-01577-4

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