Genotoxic potential of a novel PDE-4B inhibitor Apremilast by chromosomal aberration and micronucleus assay in mice

Genotoxic potential of a novel PDE-4B inhibitor Apremilast by chromosomal aberration and micronucleus assay in mice

Objective: Researchers have confirmed that chronic administration of drugs at high doses causes genotoxicity which serve as first step in development of cancers. Apremilast, a phosphodiesterase-4 inhibitor is Food and Drug Administration (FDA) approved drug for Psoriatic Arthritis. The present study...

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Bibliographic Details
Main Authors: Muhammad Afzal, Imran Kazmi, Khalid Saad Alharbi, Anwarulabedin Mohsin Quazi, Muhammad Shahid Nadeem, Nasser Hadal Alotaibi, Ameeduzzafar, Nabil K. Alruwaili, Firoz Anwar, Sattam Khulaif Alenezi, Mohammad M. Al-sanea
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Saudi Pharmaceutical Journal
Subjects:
Apremilast
Genetic damage
Chromosomal aberration
Genotoxicity
Cyclophosphamide
Mice
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016420300773

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http://www.sciencedirect.com/science/article/pii/S1319016420300773

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