Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study

Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study

Abstract Background Brain homeostasis deteriorates in sepsis, giving rise to a mostly reversible sepsis-associated encephalopathy (SAE). Some survivors experience chronic cognitive dysfunction thought to be caused by permanent brain injury. In this study, we investigated neuroaxonal pathology in sep...

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Bibliographic Details
Main Authors: Johannes Ehler, Lucinda K. Barrett, Valerie Taylor, Michael Groves, Francesco Scaravilli, Matthias Wittstock, Stephan Kolbaske, Annette Grossmann, Jörg Henschel, Martin Gloger, Tarek Sharshar, Fabrice Chretien, Francoise Gray, Gabriele Nöldge-Schomburg, Mervyn Singer, Martin Sauer, Axel Petzold
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Critical Care
Subjects:
Intermediate filaments
Biomarkers
Animal models
Rats
Sepsis
Encephalopathy
Online Access:http://link.springer.com/article/10.1186/s13054-017-1850-7

Internet

http://link.springer.com/article/10.1186/s13054-017-1850-7

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