The proteome of neurofilament-containing protein aggregates in blood

The proteome of neurofilament-containing protein aggregates in blood

Protein aggregation in biofluids is a poorly understood phenomenon. Under normal physiological conditions, fluid-borne aggregates may contain plasma or cell proteins prone to aggregation. Recent observations suggest that neurofilaments (Nf), the building blocks of neurons and a biomarker of neurodeg...

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Bibliographic Details
Main Authors: Rocco Adiutori, Johan Aarum, Irene Zubiri, Michael Bremang, Stephan Jung, Denise Sheer, Ian Pike, Andrea Malaspina
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Neurofilaments
Protein aggregates
MS-based proteomics
Blood biomarkers
Ultracentrifugation
Seprion PAD-Beads
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580818300104

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http://www.sciencedirect.com/science/article/pii/S2405580818300104

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