The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release

The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release

The myeloid inhibitory C-type lectin receptor CLEC12A limits neutrophil activation, pro-inflammatory pathways and disease in mouse models of inflammatory arthritis by a molecular mechanism that remains poorly understood. We addressed how CLEC12A-mediated inhibitory signaling counteracts activating s...

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Bibliographic Details
Main Authors: Guillaume Paré, Julien Vitry, Michael L. Merchant, Myriam Vaillancourt, Andréa Murru, Yunyun Shen, Sabine Elowe, Mireille H. Lahoud, Paul H. Naccache, Kenneth R. McLeish, Maria J. Fernandes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
C-type lectin inhibitory receptor
CLEC12A protein
signaling/signaling pathways
neutrophil
inflammation
gout
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.650808/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.650808/full

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