Ligand binding and signaling of dendritic cell immunoreceptor (DCIR) is modulated by the glycosylation of the carbohydrate recognition domain.

Ligand binding and signaling of dendritic cell immunoreceptor (DCIR) is modulated by the glycosylation of the carbohydrate recognition domain.

C-type lectins are innate receptors expressed on antigen-presenting cells that are involved in the recognition of glycosylated pathogens and self-glycoproteins. Upon ligand binding, internalization and/or signaling often occur. Little is known on the glycan specificity and ligands of the Dendritic C...

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Bibliographic Details
Main Authors: Karien Bloem, Ilona M Vuist, Arend-Jan van der Plas, Léon M J Knippels, Johan Garssen, Juan J García-Vallejo, Sandra J van Vliet, Yvette van Kooyk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3679074?pdf=render

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http://europepmc.org/articles/PMC3679074?pdf=render

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