Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury

Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury

Patients with critical illness such as acute lung injury often undergo mechanical ventilation in the intensive care unit. Though lifesaving in many instances, mechanical ventilation often results in ventilator induced lung injury (VILI), characterized by overdistension of lung tissue leading to rele...

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Bibliographic Details
Main Authors: Gabriel T. Kelly, Reem Faraj, Yao Zhang, Emin Maltepe, Jeffrey R. Fineman, Stephen M. Black, Ting Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Physiology
Subjects:
ARDS
VILI
focal adhesion
mechanical stress
cyclic stretch
integrin β4
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00511/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00511/full

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