Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra.
Parkinson disease (PD) is characterized by the preferential, but poorly understood, vulnerability to degeneration of midbrain dopaminergic (mDA) neurons in the ventral substantia nigra compacta (vSNc). These sensitive mDA neurons express Pitx3, a transcription factor that is critical for their survi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-12-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4263397?pdf=render |