Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway

Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway

Myocardial fibrosis (MF) plays a key role in the development and progression of heart failure (HF) with limited effective therapies. Galectin-3 (Gal-3) is a biomarker associated with fibrosis and inflammation in patients with HF. The Gal-3 inhibitor modified citrus pectin (MCP) protects against card...

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Bibliographic Details
Main Authors: Geng-Rui Xu, Chuang Zhang, Hong-Xia Yang, Jia-Huan Sun, Yue Zhang, Ting-ting Yao, Yuan Li, Lin Ruan, Ran An, Ai-Ying Li
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Modified citrus pectin
Myocardial fibrosis
Heart failure
Galectin-3
TLR4
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220302626

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http://www.sciencedirect.com/science/article/pii/S0753332220302626

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