ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

Many factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage at single-nucleotide resolution across the human genome and find that binding sites of ETS transcription factors are especially prone to forming UV lesions, leading to mutation hotspots in melanoma.

Bibliographic Details
Main Authors: Peng Mao, Alexander J. Brown, Shingo Esaki, Svetlana Lockwood, Gregory M. K. Poon, Michael J. Smerdon, Steven A. Roberts, John J. Wyrick
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05064-0

Internet

https://doi.org/10.1038/s41467-018-05064-0

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